Pharmacokinetic Parameter | Stavudine | Total Radioactivity |
---|---|---|
Cmax (ng/ml or ng-Eq/ml), mean (CV%) | 1372.9 (19.0) | 1593.2 (17.0) |
AUC(INF) (ng·h/ml or ng-Eq·h/ml), mean (CV%) | 3362.9 (15.0) | 5524.3 (19.0) |
Tmax (h), median (min, max) | 0.5 (0.5, 0.5) | 0.5 (0.5, 1.0) |
T-half (h), mean (S.D.) | 2.3 (0.5) | 2.4 (0.6) |
CLR (ml/min), mean (S.D.) | 272.5 (80.3) | 258.8 (54.1) |
CLT/F (ml/min), mean (S.D.) | 400.4 (61.3) | 245.3 (49.2) |
%UR, mean (S.D.) | 67.2 (14.9) | 95.1 (11.0) |
%FE, mean (S.D.) | N.A. | 2.7 (4.2) |
%Total, mean (S.D.)a | N.A. | 97.8 (10.3) |
N.A., not applicable.
↵a %Total, percent of total administered dose recovered in urine and feces.