TABLE 1

Pharmacokinetic parameters for [¹²⁵I]T₄ after the administration of [¹²⁵I]T₄ to the KC500-pretreated animals

The pharmacokinetic parameters of [¹²⁵I]T₄ were calculated from the data in Fig. 6 with noncompartmental methods as described previously (Tabata et al., 1999). The values shown are expressed as the mean ± S.E. for four to 11 animals.

Animal	Pretreatment	Dose	Mean Total Body Clearance × 100	Distribution Volume
		mg/kg	ml/min	ml
Mice	Control		1.56 ± 0.15	4.46 ± 0.25
	KC500	37.5	1.65 ± 0.20	4.69 ± 0.31
	KC500	100	2.66 ± 0.22*	6.52 ± 0.51*
Hamsters	Control		3.63 ± 0.32	10.46 ± 0.53
	KC500	37.5	5.35 ± 0.93	25.76 ± 1.21*
	KC500	100	8.19 ± 1.24*	42.04 ± 4.50*
Rats	Control		7.83 ± 0.39	15.62 ± 0.68
	KC500	37.5	13.23 ± 1.46*	31.81 ± 3.31*
	KC500	100	30.75 ± 3.27*	64.06 ± 4.58*
Guinea pigs	Control		13.73 ± 0.91	35.70 ± 2.77
	KC500	37.5	20.65 ± 1.54*	54.70 ± 4.70*
	KC500	100	23.42 ± 2.17*	65.42 ± 4.98*

↵* P < 0.05, significantly different from each control.