Accumulation of [125I]T4 in the KC500-pretreated mice, hamsters, rats, and guinea pigs livers
The radioactivity in the liver was measured at 60 min after the [125I]T4-administration, as described under Materials and Methods. Accumulation levels of the liver in the control mice, hamsters, rats, and guinea pigs were 292620 ± 8873 (n = 4), 577975 ± 51307 (n = 4), 568665 ± 16375 (n = 6), and 121496 ± 4234 (n = 4) cpm/g wet liver, respectively. The values shown are expressed as the mean ± S.E. for four to six animals.
| Animal | [125I]T4 | |
|---|---|---|
| Control | KC500 | |
| % of dose/g liver | ||
| Mice | 10.03 ± 0.13 | 15.34 ± 0.90* |
| Hamsters | 6.93 ± 0.59 | 10.41 ± 1.03* |
| Rats | 2.75 ± 0.12 | 3.95 ± 0.33* |
| Guinea pigs | 0.45 ± 0.02 | 0.76 ± 0.05* |
↵* P < 0.05, significantly different from each control.