Lersivirine pharmacokinetic parameter values (geometric means and intersubject variability)
| PK Parameter (Units) | Lersivirine (Plasma) | Total Drug-Related Radioactivity (Plasma) | Total Drug-Related Radioactivity (Whole Blood) |
|---|---|---|---|
| n | 4 | 4 | 4 |
| AUCinf (ng · h/ml)a,b | 4100 (19) | 39,130 (4) | 18,650 (7) |
| Cmax (ng/ml)a,b | 1010 (40) | 6042 (21) | 2767 (27) |
| Tmax (h)c | 1.50 (0.50–3.00) | 1.50 (1.00–3.00) | 1.50 (1.00–3.00) |
| t½ (h)d | 5.83 (26) | 9.41 (30) | 9.91 (19) |
| CL/F (l/h)b | 122 (18) | 12.78 (4) | 26.81 (7) |
| Vz/F (liter)b | 994 (24) | 169.4 (26) | 37,804 (15) |
AUCinf, area under the plasma concentration-time profile from time zero extrapolated to infinite time; CL/F, apparent clearance; Cmax, maximum plasma concentration; t½, terminal half-life; Tmax, time to reach maximum concentration; VZ/F, apparent volume of distribution.
↵a Units for radioactive compound are ng-Eq · h/g for AUCinf and ng-Eq/g for Cmax.
↵b Geometric mean (percentage coefficient of variation).
↵c Median (range).
↵d Arithmetic mean (percentage coefficient of variation).