TABLE 4

Dose proportions of deferasirox and metabolites excreted in feces and urine

Data are means ± S.D.; n = 5. Feces fractions 0 to 168 h and urine fractions 0 to 72 h were pooled.

CompoundFecesUrineTotal
% dose
M1: 5-hydroxy metabolite of deferasirox4.4 ± 2.6N.D.4.4 ± 2.6
M3: acyl glucuronide of deferasiroxN.D.0.2 ± 0.10.2 ± 0.1
M4: 5′-hydroxy metabolite of deferasirox1.9 ± 0.6N.D.1.9 ± 0.6
M6: 2-O-glucuronideN.D.6.3 ± 2.96.3 ± 2.9
M7: 5-O-sulfate conjugate of M12.0 ± 2.40.3 ± 0.12.3 ± 2.4
Total of metabolites8.3 ± 2.06.8 ± 3.015.1 ± 4.5
Deferasirox60.4 ± 7.20.5 ± 0.460.9 ± 7.4
Not recovered from extraction and HPLC and unidentified traces14.4 ± 8.40.2 ± 0.214.6 ± 8.3
Total of drug and metabolites83.1 ± 4.07.5 ± 2.990.6 ± 1.8
  • N.D., not detected.