TABLE 2

Summary of meta-analysis

AUC was calculated from 0 h to infinity. Values in parentheses are 95% CIs.

Pharmacokinetic ParametersNo. of StudiesNo. of Participants (No. of Women)Statistical MethodEffect SizePTest for HeterogeneityEgger Test: P
χ2PI2
%
CLpo8307 (148)WMD (fixed), 95% CI0.20 (0.11 to 0.28)<0.001*11.890.10410.277
CLiv7309 (153)WMD (random), 95% CI0.08 (0.03 to 0.13)0.002*21.320.002720.686
AUCpo8307 (148)SMD (fixed), 95% CI−0.05 (−0.28 to 0.17)0.647.330.4040.574
AUCiv6269 (132)SMD (fixed), 95% CI−0.29 (−0.53 to −0.04)0.02†8.330.14400.872
F6243 (116)WMD (fixed), 95% CI−0.01 (−0.03 to 0.02)0.637.950.16370.658
EG5203 (95)WMD (random), 95% CI−0.06 (−0.15 to 0.04)0.259.330.0557N.E.

  • N.E., Egger test was not done if fewer than six studies were included.

  • ↵* Significantly higher in women at 0.01 level of significance.

  • ↵† Significantly higher in men at 0.05 level of significance.