Biological half-lives of 14C in tissues of male and female rats after repeated oral administration of [dichlorophenyl-14C]pyridalyl at a rate of 5 mg/kg/day daily for 14 successive days
| Tissue | Biological Half-Life Time | |||
|---|---|---|---|---|
| Male | Female | |||
| α Phase | β Phase | α Phase | β Phase | |
| days (calculation days) | days (calculation days) | days (calculation days) | days (calculation days) | |
| Adrenals | 5 (Days 14–20) | 9 (Days 20–27) | 3 (Days 14–17) | 7 (Days 17–27) |
| Blood | 2 (Days 14–20) | — | 1 (Days 14–17) | — |
| Plasma | 2 (Days 14–20) | — | 2 (Days 14–20) | — |
| Red blood cells | — | — | — | — |
| Brain | 1 (Days 14–17) | 9 (Days 17–27) | 2 (Days 14–17) | — |
| Fat (brown) | 2 (Days 14–20) | 7 (Days 20–27) | 3 (Days 14–20) | 14 (Days 20–27) |
| Fat (perirenal) | — | 10 (Days 17–27) | — | 11 (Days 17–27) |
| Fat (testicular) | — | 15 (Days 17–27) | — | — |
| Heart | 2 (Days 14–17) | 7 (Days 17–27) | 2 (Days 14–17) | 7 (Days 17–27) |
| Kidneys | 2 (Days 14–17) | 10 (Days 17–27) | 2 (Days 14–17) | 9 (Days 17–27) |
| Liver | 1 (Days 14–17) | 4 (Days 17–27) | 1 (Days 14–17) | 5 (Days 17–27) |
| Lungs | 2 (Days 14–20) | 13 (Days 20–27) | 2 (Days 14–20) | 6 (Days 20–27) |
| Muscle | 4 (Days 14–17) | 9 (Days 17–27) | 3 (Days 14–17) | 7 (Days 17–27) |
| Ovaries | — | — | 4 (Days 14–17) | 24 (Days 17–27) |
| Skin | — | 9 (Days 14–27) | — | 6 (Days 17–27) |
| Spleen | 2 (Days 14–17) | 10 (Days 17–27) | 3 (Days 14–17) | 8 (Days 17–27) |
| Testes | 2 (Days 14–17) | 14 (Days 17–27) | — | — |
| Thymus | 4 (Days 14–27) | — | 5 (Days 14–27) | — |
| Thyroids | 1 (Days 14–17) | 8 (Days 17–27) | 4 (Days 14–20) | 5 (Days 20–27) |
| Uterus | — | — | — | 10 (Days 14–27) |
—, not calculated.