Dose | Parameter Used for Iu | Unbound Concentration | E′ss/Ess | AUCi/AUC | ||
---|---|---|---|---|---|---|
Predicted | Observed | Predicted | Observed | |||
nM | ||||||
2 mg/kg | Cmax | 2.32 ± 1.5 | 0.93 ± 0.04 | 1.07 ± 0.043 | ||
Cave | 0.15 ± 0.06 | 1.00 ± 0.002 | 0.795 ± 0.04 | 1.00 ± 0.0017 | 1.19 ± 0.90 | |
Cterminal | 0.24 ± 0.12 | 0.99 ± 0.004 | 1.01 ± 0.0034 | |||
20 mg/kg | Cmax | 60.8 ± 8.1 | 0.35 ± 0.029 | 2.65 ± 0.20 | ||
Cave | 2.71 ± 0.36 | 0.92 ± 0.010 | 0.376 ± 0.026 | 1.08 ± 0.011 | 3.62 ± 0.84 | |
Cterminal | 1.77 ± 0.39 | 0.95 ± 0.011 | 1.12 ± 0.011 |