TABLE 1

Summary of CYP2C9 inhibition by CYP3A4

CYP2C9/CYP3A4/CPR/b5Isoform Being TestedSubstratePercentage Inhibition in Vmax
1:1:2:0CYP2C9Naproxen71 ± 3.46
1:2:2:0CYP2C9Naproxen84 ± 0
1:1:4:0CYP2C9Naproxen65 ± 5.7
1:2:4:0CYP2C9Naproxen75 ± 0
1:1:2:0CYP2C9Flurbiprofen62.5 ± 4.6
1:1:2:0 rCPRCYP2C9Flurbiprofen65.3 ± 2.1
1:2:2:0CYP2C9Flurbiprofen73.8 ± 5.5
1:1:4:0CYP2C9Flurbiprofen42.4 ± 5.8
1:1:4:0 rCPRCYP2C9Flurbiprofen41.6 ± 6.2
1:2:4:0CYP2C9Flurbiprofen64.2 ± 5.5
1:1:2:1CYP2C9Flurbiprofen54.6 ± 2.6