Substrate/Enzyme | Primary Amine | Secondary Hydroxylamine | MI Complex | MRa | BRb |
---|---|---|---|---|---|
μM | μM | μM | |||
Desipramine/CYP2C11 | 0.89 (0.10) | 0.23 (0.01) | 0.08 (0.01) | 3.9 (0.5) | 2.9 (0.4) |
(S)-Fluoxetine/CYP2C19 | 0.50 (0.01) | 0.030 (0.001) | 0.11 (0.01) | 17 (1) | 3.6 (0.4) |
N-Desmethyldiltiazem/CYP3A4 | 0.23 (0.02) | 0.10 (0.01) | 0.19 (0.01) | 2.4 (0.3) | 0.80 (0.09) |
Desipramine-methyl-d3/CYP2C11 | 0.40 (0.04) | 0.27 (0.02) | 0.07 (0.02) | 1.5 (0.2) | 1.2 (0.4) |