TABLE 1
Overview of identified SZ metabolites
| Metabolite | Putative Structural Formula | RT | Comments |
|---|---|---|---|
| min | |||
| SZ | 52 | Parent drug mol. wt.: 348 g/mol | |
| M362 | 47 | Hydroxylation position to be confirmed by synthesis | |
| M364d | 42 | Hydroxylation position to be confirmed by synthesis | |
| M364c (EMD 329989) | 41 | Structure proven | |
| M364a (EMD 148107) | 39 | Structure proven | |
| M203 | 32 | Nicotinic alcohol: to be confirmed by NMR | |
| M217 (EMD 50929) | 23 | Nicotinic acid structure confirmed by synthesis | |
| M163 | 14 | Aminomethyl chromane be confirmed by NMR |