P450 Enzymes | Predicted Contribution | ||||||
---|---|---|---|---|---|---|---|
SZ | EMD 50929 | M203 | EMD 148107 | EMD 329989 | M364d | M362 | |
% | |||||||
CYP1A2 | 13 | 100 | 5 | 1 | 34 | 6 | 0 |
CYP2A6 | 1 | 0 | 27 | 0 | 11 | 14 | 0 |
CYP2C8 | 19 | 0 | 12 | 7 | 28 | 35 | 0 |
CYP2C9 | 23 | 0 | 11 | 69 | 8 | 3 | 0 |
CYP2C19 | 2 | 0 | 1 | 2 | 3 | 0 | 0 |
CYP2D6 | 1 | 0 | 1 | 4 | 0 | 1 | 0 |
CYP2E1 | 0 | 0 | 2 | 0 | 1 | 0 | 0 |
CYP3A4 | 41 | 0 | 40 | 18 | 15 | 40 | 0 |
Total | 100 | 100 | 100 | 100 | 100 | 100 | 0 |
RAF, relative activity factor.