P450 Marker Reaction | IC50 | ||
---|---|---|---|
EMD 50929 | EMD 148107 | EMD 329989 | |
μM | |||
Ethoxyresorufin O-deethylase (CYP1A2) | >100 | 83.5 ± 20.0 | >100 |
Tolbutamide 4-hydroxylase (CYP2C9) | >100 | 34.8 ± 4.1 | >100 |
S-Mephenytoin 4-hydroxylase (CYP2C19) | >100 | 31.9 ± 4.5 | 20.2 ± 8.7 |
Dextromethorphan O-demethylase (CYP2D6) | >100 | 12.0 ± 0.7 | 27.3 ± 5.3 |
Testosterone 6β-hydroxylase (CYP3A4) | >100 | 6.0 ± 0.3 | 2.1 ± 0.5 |