Ratio of metabolites formed to SZ metabolized in HLM and human hepatocyte culture after a 1-h incubation
| Metabolite | HLM | Human Hepatocyte Culture |
|---|---|---|
| % | ||
| EMD 148107 | 17.2 | 9.4 |
| EMD 329989 | 14.5 | 19.2 |
| M364d | 16.5 | N.D. |
| M362 | 10.2 | N.D. |
| M203 | 19.5 | N.D. |
| EMD 50929 | 8.5 | 18.7 |
| Others | 13.7 | N.D. |
| Sum | 100.0 | |
N.D., not determined.