TABLE 3

Recombinant UGT reaction phenotyping summary results

CompoundUGT Enzymes Involved in Increasing Order of Peak Area
AlprazolamUGT1A4
FluconazoleUGT2B7 > UGT1A4
ItraconazoleUGT1A4
VoriconazoleUGT1A4 ≫ UGT2B17 = UGT1A9 = UGT1A6 > UGT1A7 = UGT1A3
TioconazoleUGT1A4 > UGT2B7 > UGT1A3
KetoconazoleUGT1A4
EconazoleUGT1A4 > UGT1A3 > UGT2B7 > UGT1A6
MiconazoleUGT1A4 > UGT1A3 = UGT2B7 > UGT2B4 ≫ UGT1A1
BifonazoleUGT1A4 > UGT1A3 > UGT2B7 > UGT1A9
SulconazoleUGT1A4 > UGT1A3 > UGT2B7 > UGT1A1