Comparison of key active site residues in CYP2A enzymes
| Residues | 107 | 111 | 117 | 118 | 208 | 209 | 296 | 297 | 300 | 301 | 365 | 366 | 370 | 480 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Human CYP2A6 | F | F | V | F | I | F | L | N | I | G | V | I | L | F |
| Human CYP2A13 | F | F | A | F | S | F | L | N | F | A | M | L | L | F |
| Dog CYP2A13 | F | F | A | F | S | F | L | N | F | A | M | I | V | F |
| Dog CYP2A25 | F | F | T | F | S | F | L | N | F | A | I | I | L | F |