TABLE 1

Pharmacokinetic parameters of JBP485 and cephalexin after oral or intravenous administration

Values represent means ± S.D. (n = 5). Statistical analyses were conducted using a two-sided unpaired Student's t test.

Parameters	JBP485	JBP485 + Cephalexin	Cephalexin	Cephalexin + JBP485
Oral
C_max (μg/ml)	12.75 ± 0.77	1.75 ± 0.52^{^a}	53.97 ± 4.09	6.41 ± 1.43^{^a}
T_max (min)	60	240^{^a}	60	120^{^a}
K_a (1/min)	0.11 ± 0.0042	0.077 ± 0.0013	0.0047 ± 0.0006	0.0024 ± 0.0001
K_e (1/min)	0.0064 ± 0.0004	0.0029 ± 0.0011	0.0044 ± 0.0022	0.0021 ± 0.0016
MRT (min)	194.07 ± 1.64	469.784 ± 2.47^{^a}	208.87 ± 1.59	361.52 ± 1.94^{^b}
AUC_0→∞ (min·μg/ml)	2724.63 ± 83.81	958.97 ± 76.32^{^a}	13657.48 ± 95.10	3159.78 ± 88.23^{^a}
t_1/2β (min)	135.19 ± 4.06	247.96 ± 2.06^{^b}	86.98 ± 3.13	157.42 ± 2.69^{^b}
V_d/F (l/kg)	0.30 ± 0.02	0.67 ± 0.04	0.77 ± 0.03	1.74 ± 0.01
CL_p/F (ml/kg/min)	1.91 ± 0.32	1.93 ± 0.13	3.39 ± 0.32	3.74 ± 0.41
Intravenous
F (%)	26.1 ± 4.23	9.2 ± 0.96^{^a}	81.2 ± 9.72	18.8 ± 1.81^{^a}
C_max (μg/ml)	131.24 ± 3.21	114.36 ± 2.79	482.84 ± 5.08	476.51 ± 2.68
K_e (1/min)	0.0085 ± 0.0017	0.0098 ± 0.0004	0.0079 ± 0.0008	0.0080 ± 0.0009
MRT (min)	145.53 ± 1.84	169.83 ± 1.47	101.22 ± 1.09	102.33 ± 1.56
AUC_0→∞ (min·μg/ml)	10455.37 ± 130.17	11119.61 ± 109.61	16817.26 ± 163.34	16716.96 ± 128.52
t_1/2β (min)	134.24 ± 1.02	132.86 ± 1.31	86.80 ± 2.01	87.48 ± 1.36
V_d (l/kg)	0.28 ± 0.04	0.23 ± 0.01	0.42 ± 0.03	0.42 ± 0.05
CL_p (ml/kg/min)	2.39 ± 0.19	2.25 ± 0.15	3.32 ± 0.32	3.36 ± 0.18
CL_R (ml/kg/min)	2.23 ± 0.16	1.58 ± 0.09^{^b}	2.89 ± 0.15	1.87 ± 0.15^{^b}