Effect of particle size on oral exposures of GDC-0449 after oral administration of capsules containing a 150-mg total dose to male dogs (n = 6/group)
| Treatment | Cmax | Tmax | AUC0–168 |
|---|---|---|---|
| μM | h | μM · h | |
| 150-mg capsule | 8.12 ± 4.01 | 4.0 | 453 ± 271 |
| (small particles) | (4.0–4.0) | ||
| 25 + 125-mg capsules | 2.66 ± 1.56 | 3.0 | 150 ± 95 |
| (large particles) | (1.0–4.0) |
AUC0–168, area under the plasma concentration-time profile from time 0 to 168 h postdose; Cmax, highest observed plasma concentration; Tmax, time at which Cmax occurred.