Model parameters used in clarithromycin simulation
| Parameters | Values | References |
|---|---|---|
| Molecular weight | 747.96 | Biaxin package insert, Abbott Laboratories, Abbott Park, IL, 2009 |
| pKa | 8.76 | N. Vyas, J. Hargrave, J. Lai, S. Lamb, K. Qian, and G. Venkatesh, http://www.eurand.com/pdf/eurx_posters_2005.pdf |
| Blood/plasma ratio | 0.854 | Assumed to be the same as erythromycin |
| ka (h−1) | 3.38 | Chu et al., 1993 |
| fa | 0.9 | Ferrero et al., 1990 |
| Vss (CV) (l/kg) | 1.75 (21.6%) | Chu et al., 1992 |
| CLi.v. (CV) (l/h) | 31.14 (26%) | Chu et al., 1992 |
| CLR (l/kg) | 7.2 | Chu et al., 1993 |
| fu, p | 0.48 | Suwa et al., 1988 |
| Ki (μM) | 330 | Gascon and Dayer, 1991 |
| kinact (h−1) | 1.8 | Merck unpublished data |
| KI (μM) | 4.56 | Merck unpublished data |
| fu, mic | 0.804 | Simcyp predicted |