TABLE 3

Key inhibitor parameters provided in the Simcyp program

Inhibitorkafu, pMechanism-Based InhibitionCompetitive Inhibition
KIkinactfu, micKifu, mic
h1μMh1μM
Diltiazem1.690.2483.34.20.9N.A.N.A.
Erythromycin0.260.3113.41.490.972820.909
Ritonavira0.240.020.17240.859b0.0250.662
Saquinavira2.550.0250.6515.60.908b3.50.58
Verapamil1.220.1041.85.30.77N.A.N.A.
Fluoxetinec0.970.0793.30.780.176b670.051
  • N.A., not available in the Simcyp program.

  • a KI and kinact for mechanism-based inhibition are from Ernest et al., 2005.

  • b fu,mic values were predicted using the Predictor provided in the Simcyp program.

  • c KI and kinact for mechanism-based inhibition are from Merck (unpublished data).