Pharmacokinetic parameters of lidocaine, midazolam, and nifedipine after intra-portal and intravenous administration to rats
Each CL was calculated as dose/AUC. Values are expressed as the mean ± S.E.; n = 3.
| Compound | Administration Route | AUC | CL | Elung |
|---|---|---|---|---|
| μ M … min | ml/min/kg | % | ||
| Lidocaine | i.p. | 0.0817 ± 0.0118 | 457 ± 72 | 68.0 ± 3.3 |
| i.v. | 0.255 ± 0.058 | 145 ± 32 | ||
| Midazolam | i.p. | 0.167 ± 0.044 | 184 ± 65 | 52.6 ± 0.4 |
| i.v. | 0.353 ± 0.029 | 87.0 ± 6.7 | ||
| Nifedipine | i.p. | 3.16 ± 0.34 | 9.13 ± 1.34 | 13.5 ± 0.2 |
| i.v. | 3.65 ± 0.31 | 7.90 ± 0.72 |
i.p., intraportal administration; CL, total plasma clearance.