Summary of estimated pharmacokinetic parameters after intravenous administration of CJ-13,610 to rats and dogs (n = 3) using noncompartmental pharmacokinetic analysis
Numbers in parentheses are S.D.
| Pharmacokinetic Parameter | Rat | Dog |
|---|---|---|
| Dose (mg/kg) | 0.5 | 0.1 |
| AUC (μM … h) | 1.83 (0.11) | 0.94 (0.04) |
| Clearance (ml/min/kg) | 11.5 (0.69) | 4.4 (0.17) |
| Vdss (l/kg) | 3.6 (0.17) | 2.9 (0.29) |
| MRT (h) | 5.2 (0.4) | 11 (1.5) |