Permeability in artificial membranes and Fa in humans
| Reference Compounds | Papp | Faa | Model Compounds | Papp |
|---|---|---|---|---|
| (×10−6 cm/s) | (×10−6 cm/s) | |||
| Acetaminophen | 2.8 | 0.80 | Alprazolam | 7.0 |
| Acyclovir | 0.0 | 0.21 | Amlodipine | 19.5 |
| Alprenolol | 37.2 | 0.94 | Clonazepam | 18.6 |
| Amphotericin B | 0.0 | 0.05 | Midazolam | 30.8 |
| Antipyrine | 2.6 | 1.00 | Nifedipine | 13.4 |
| Atenolol | 0.1 | 0.52 | Nicardipine | 31.5 |
| Caffeine | 2.0 | 1.00 | Quinidine | 17.9 |
| Carbamazepine | 27.7 | 1.00 | Tacrolimus | 34.3 |
| Diclofenac | 32.9 | 1.00 | Verapamil | 35.8 |
| Furosemide | 0.2 | 0.60 | ||
| Hydrochlorothiazide | 0.1 | 0.70 | ||
| Indomethacin | 22.4 | 1.00 | ||
| Ketoprofen | 12.7 | 1.00 | ||
| Ketorolac | 4.0 | 1.00 | ||
| Metoprolol | 11.3 | 0.95 | ||
| Nadolol | 0.0 | 0.32 | ||
| Naproxen | 11.1 | 0.98 | ||
| Piroxicam | 16.1 | 1.00 | ||
| Prednisone | 14.3 | 0.99 | ||
| Propranolol | 37.4 | 0.93 | ||
| Ranitidine | 0.1 | 0.55 | ||
| Sulpiride | 0.0 | 0.36 | ||
| Terbutaline | 0.7 | 0.68 | ||
| Theophylline | 1.8 | 0.97 | ||
| Warfarin | 12.9 | 0.97 |
↵a Quoted from Zhu et al. (2002).