Description of bias (gmfe) and percentage within 1.5-fold of unity for predictions of the FG for either total set of 25 drugs or for a subset of 11 drugs for which in vivo FG < 0.5
Different permeability approaches were used as follows: 1, Papp (A-B) data from Caco-2 (data in parentheses: MDCK-MDR1); 2, Peff data from correlation to Papp (A-B) from Caco-2 (data in parentheses: MDCK-MDR1); 3, Peff data from correlation to Papp (A-B) from Caco-2 (data in parentheses: MDCK-MDR1) calibrated for midazolam QGut; and 4, Peff data from correlation to in silico data (data in parentheses: calibrated for midazolam QGut).
| 1 | 2 | 3 | 4 | |
|---|---|---|---|---|
| Total set of drugs (n = 25) | ||||
| <1.5-Fold (%) | 64 (60) | 52 (60) | 56 (60) | 44 (44) |
| gmfe | 1.82 (1.74) | 2.29 (2.14) | 1.89 (1.89) | 3.93 (3.34) |
| Drugs with in vivo FG < 0.5 (n = 11) | ||||
| <1.5-Fold (%) | 27 (18) | 18 (27) | 9 (18) | 18 (9) |
| gmfe | 2.89 (2.67) | 4.15 (3.65) | 2.82 (2.74) | 9.55 (7.35) |