TABLE 5

PK parameters, F, F_h, and F_aF_g of cyclosporine and felodipine in humans

PK parameters were quoted from reference as follows: cyclosporine (Gupta et al., 1990); felodipine (Hardman et al., 1996).

	CL_tot,p	R_b	CL_tot,b	CL_r	CL_h	F	Q_h
							17.1		20.7		25.5
							F_h	F_aF_g	F_h	F_aF_g	F_h	F_aF_g
	ml/min/kg		ml/min/kg	ml/min/kg	ml/min/kg
Cyclosporine			6.60	0^{^a}	6.60	0.420	0.614	0.684	0.681	0.617	0.741	0.567
Felodipine	12.00	1.45	8.23	0^{^a}	8.23	0.150	0.516	0.291	0.600	0.250	0.675	0.222