TABLE 1

ERL tissue distribution

Drug levels were determined 2 h after a single 10-mg/kg oral dose in C57BL/6 mice. Tissues were not perfused to ensure ERL was not washed out during perfusion.

Tissue ERL Concentration
PlasmaBrainLiverLung
μM
ERL5.4 ± 1.60.37 ± 0.1414.7 ± 2.85.0 ± 1.2