Position | Addition | V | Inhibitory Ratio | |
---|---|---|---|---|
pmol/(min · pmol) CYP3A4 | % | |||
Control | 2 μM Midazolam alone | 8.67 | 100 | |
Positive control | +100 nM Ketoconazole | 4.45 | 51 | |
+10 μM Furanocoumarin | +Psoralen | 10.60 | 122 | |
Side chain | 5 | +Bergapten | 7.76 | 90 |
+Isoimperatorin | 9.78 | 112 | ||
+Oxypeucedanin | 8.96 | 103 | ||
+Oxypeucedanin hydrate | 8.32 | 95 | ||
+Notopterol | 4.09 | 54 | ||
8 | +Imperatorin | 9.13 | 112 | |
+Heraclenin | 7.32 | 84 | ||
+Heraclenol | 9.06 | 104 | ||
5 and 8 | +Byakangelicol | 8.19 | 94 | |
+Byakangelicin | 8.13 | 93 | ||
Dimer | +Rivulobirin A | 3.68 | 42 |