Position | Addition | Papp, AB | Papp, BA | Efflux Ratio | |
---|---|---|---|---|---|
×10−5 cm/s | |||||
Control | 10 μM Digoxin | 0.66 ± 0.05 | 19.20 ± 1.26 | 29.20 | |
Positive control +10 μM Furanocoumarin | +20 μM Cyclosporine A | 5.21 ± 0.47 | 5.50 ± 1.18 | 1.06** | |
Side chain | 5 | +Notopterol | 0.96 ± 0.08 | 17.80 ± 1.71 | 18.50 |
5 and 8 | +Byakangelicol | 1.77 ± 0.16 | 14.10 ± 1.32 | 7.97** | |
Dimer | +Rivulobirin A | 2.88 ± 0.31 | 10.70 ± 2.12 | 3.72** |
↵** Significant at p < 0.01 vs. control.