Overview of MCP metabolites identified in human urine and subcellular fractions from human liver
| Metabolite(s) | Type of Metabolic Pathway | Matrix (Type of In Vitro Incubation) | Key Fragments: MS and MSn | Retention Time |
|---|---|---|---|---|
| m/z | min | |||
| M1 | Oxidation, followed by glucuronidation | HLM (P450 + UGT), human urine | 492, 419, 316, 300, 227, 243, 184, 143 | 2.9 |
| M2 | Sulfonylation | HLC (SULT), human urine | 380, 300, 227 | 5.7 |
| M3 | N-dealkylation | HLM (P450), human urine | 272, 227, 184, 115 | 6.2 |
| M4 | Oxidation | HLM (P450), human urine | 316, 242, 117, 100 | 6.5 |
| M5 | Oxidative deamination, followed by oxidation | HLM (P450), human urine | 259, 184, 115 | 12.0 |
| M6 | Oxidation followed by glucuronidation | HLM (P450 + UGT) | 492, 419, 376, 316, 243 | 1.8 |
| M7 | Glucuronidation | HLM (UGT and P450 + UGT) | 476, 403, 360, 300 | 2.1 |
| M8 | Oxidation followed by glucuronidation | HLM (P450 + UGT) | 492, 419, 376, 316, 243 | 2.7 |
| M9 | N-carbamoylation | HLM (P450) | 344, 271, 228, 117, 100 | 10.0 |
| M10 | Nitro formation | HLM (P450) | 330, 257, 214 | 12.0 |
| MCP | Parent compound | N.A. | 300, 272, 227, 184, 143, 117, 115, 100, 89 | 10.4 |
N.A., not applicable.