TABLE 1

In vitro inhibition by propiverine, M-1, and M-2 of specific [3H]NMS binding in the rat bladder and submaxillary gland

Values are the mean ± S.E. for three or four rats.

BladderSubmaxillary Gland
Hill CoefficientKi ValueHill CoefficientKi Value
μMμM
Propiverine0.87 ± 0.020.30 ± 0.041.03 ± 0.030.19 ± 0.01†
M-10.96 ± 0.066.50 ± 0.62***0.99 ± 0.083.92 ± 0.27***,†
M-21.00 ± 0.060.21 ± 0.010.97 ± 0.060.12 ± 0.02†

  • ↵*** P < 0.001, asterisks show a significant difference from the values for propiverine.

  • ↵† P < 0.05, daggers show a significant difference from the value for bladder.