Inhibition of ramelteon metabolism by fluvoxamine
Values represent the mean (S.E.) of triplicate determinations. Ramelteon concentration was 10 μM.
| Metabolite | IC50 |
|---|---|
| μM | |
| A | 0.50 (0.11) |
| B | 2.7 (0.9) |
| C | 56 (11) |
| D | 0.62 (0.13) |
| E | 1.1 (0.3) |
| F | 0.99 (0.29) |
| G | 58 (15) |