TABLE 4

In vitro intrinsic clearance data for drugs in pooled human liver cytosol and S-9 fractions

The cytosol reaction values are an average of n = 4; therefore, an average %CV of 4% was observed.

Drug	Cytosol In Vitro t_1/2^{^a}	S-9 In Vitro t_1/2^{^a}	Scaled Cytosol CL′_int	Scaled S-9 CL′_int
	min	min	ml/(min · kg)	ml/(min · kg)
O⁶-Benzylguanine	33	15	36	47
Carbazeran	3.6	1.1	323	611
DACA	11	10	111	69
6-Deoxypenciclovir	41	5.8	29	122
Methotrexate	480	120	<2.5	<5.9
PF-945863	34	19	35	36
PF-4217903	530	119	2.2	5.9
RS-8359	165	24	7.1	29
XK-469	480	120	<2.5	<5.9
Zaleplon	194	93	6.1	7.6
Zoniporide	31	22	37	32

CV, coefficient of variation.
↵a The S-9 values are an average of n = 2, and, on average, the replicates were within 8.5% of the mean t_1/2 value.