Sample No. | Gender | Age | BMI | Race | Smoker | Alcohol User | CDNB Activity (nmol CDNB conjugate/min/mg total protein) | GSTM1 Expression | GSTA1 Expression | rev BPDE-7-NAC (pmol/ml)b | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
12 h | 24 h | ||||||||||||
Peak 1 | Peak 2 | Peak 1 | Peak 2 | ||||||||||
1065 | F | 69 | 31 | Caucasian | No | No | 42 | + | + | ND | 0.34 | 0.28 | 10.1 |
1066 | F | 44 | 20 | Caucasian | No | Yes | 46 | + | ND | ND | 0.08 | 0.12 | |
1071 | M | 54 | 24 | African-American | No | No | 25 | + | 0.01 | 0.05 | 0.17 | 0.72 | |
1072 | F | 66 | 30 | Caucasian | Yes | No | 42 | + | 0.04 | 0.14 | 0.22 | 1.29 | |
1075 | F | 40 | 35 | Caucasian | No | No | 45 | + | + | ND | 0.24 | 0.1 | 2.4 |
1078 | M | 66 | 28 | Caucasian | No | No | 43 | + | ND | ND | 0.07 | 0.16 | |
1081 | F | 56 | 25 | Caucasian | No | No | 111 | + | ND | ND | 0.17 | 0.33 | |
1085 | F | 43 | 27 | Caucasian | No | No | 163 | + | + | 0.06 | 1.89 | 0.43 | 17 |
1088 | M | 58 | 22 | Caucasian | Yes | Yes | 74 | + | 0.04 | 0.06 | 0.07 | 0.18 | |
1091 | M | 47 | 30 | Caucasian | No | Yes | 61 | + | + | ND | 0.005 | ND | 0.19 |
Mean ± S.D.c | 54 ± 11 | 27 ± 4.5 | 65.2 ± 41.8 | 0.017 ± 0.23 | 0.30 ± 0.61 | 0.18 ± 0.12 | 3.59 ± 5.95 |
BMI, body mass index; F, female; ND, not detected; M, male.
↵a Hepatocytes were incubated with 10 μM BPDE or rev-BPDE, except sample 1091 (1 μM).
↵b BPDE-10-NAC was detected in only one sample, no. 1085, 0.015 (12 h) and 0.035 (24 h) pmol/ml.
↵c Means for rev-BPDE-7-NAC are based on the nine samples in which the concentration of rev-BPDE was 10 μM.