Ratio of brain/plasma ratios of [14C]sorafenib in mdr1a/1b(−/−) and WT mice after intravenous or oral administration as its tosylate
n = 3 animals/time point.
| Time | Dose (Related to Sorafenib) | ||
|---|---|---|---|
| Intravenous: 0.5 mg/kg | Oral | ||
| 0.5 mg/kg | 4 mg/kg | ||
| 0.5 h | 1.30 | ||
| 1 h | 1.25 | 1.28 | 1.48 |
| 2 h | 1.50 | ||
| 4 h | 1.27 | 0.964 | 1.54 |