Summary of pharmacokinetic parameters in male FVBn (wild-type), Mdr1a/b(−/−), Bcrp1(−/−), and Mdr1a/b(−/−)/Bcrp1(−/−) knockout mice
| Study | Mice | CLp | t1/2 | Vss | AUCpo |
|---|---|---|---|---|---|
| ml/(min · kg) | h | l/kg | μM × h | ||
| 1 | FVBn | 25.5 | 0.44 | 1.26 | 9.09 |
| Mdr1a/b(−/−) | 35.5 | 0.71 | 1.06 | 10.1 | |
| 2 | FVBn | 15.5 | 1.05 | 0.98 | 18.8 |
| Bcrp1(−/−) | 18.2 | 0.9 | 1.03 | 19.3 | |
| 3 | FVBn | 20.1 | 0.82 | 0.96 | 10.5 |
| Mdr1a/b(−/−)/Bcrp1(−/−) | 20.4 | 0.85 | 0.99 | 13.1 |
CLp, plasma clearance; t1/2, terminal half-life; Vss, volume of distribution at steady state; AUC, area under the curve.