TABLE 2

Brain penetration (Br/Bl) of paracellular markers in EAE and naive mice after intravenous administration

Compound	Dosing Regimen	Sample Time	Naive	EAE
Atenolol	Intravenous bolus (5 mg/kg, n = 5)	10 min	0.005 ± 0.002	0.014 ± 0.002^*
	Intravenous infusion (10 mg/h/kg)^{^a}	2.5 h	0.014 ± 0.003	0.015 ± 0.001
	Intravenous bolus (6 mg/kg)-intravenous infusion (10 mg/h/kg, n = 3)	10 min	0.005 ± 0.001	Not carried out
		2.5 h	0.010 ± 0.002^*
NaF	Intravenous bolus (500 mg/kg, n = 3)	10 min	0.040 ± 0.014	0.129 ± 0.002^*

↵* p < 0.01.
↵a Br/Bl in naive and EAE mice was derived from four and two animals, respectively.