TABLE 2

Pharmacodynamic parameters estimated from MCF7.1 tumor xenograft studies

ParameterEstimateCV
%
kng (h−1)0.00275.73
Kmax (h−1)0.00514.07
KC50 (μM)0.2317.5
n1 (fixed)
ED50 (mg/kg)16
Cstasis (μM)0.26

  • CV, coefficient of variation.