TABLE 2

Comparison between the actual and classified pathways: drugs classified as dual pathways

Charge and Drug Name	Classified Pathway
Charge and Drug Name	CYP3A4	CYP2C9	CYP2D6	Renal	OATP
Cation/neutral
Clonazepam	○^{^a}		○
Chlorpromazine	○		○^{^a}
Diphenhydramine	○		○^{^a}
Doxepin	○		○^{^a}
Fluoxetine	○		○^{^a}
Imipramine	○^{^b}		○^{^a}
Nortriptyline	○		○^{^a}
Tolterodine	○^{^b}		○^{^a}
Anion
Dicloxacillin				○^{^a}	○^{^c}
Enalapril				○^{^b}	○^{^a}
Pravastatin				○^{^b}	○^{^a}
Rifampin	—^{^b}			○	○^{^a}
Rosuvastatin		—^{^b}		○	○^{^a}
Temocaprilat				○^{^b}	○^{^a}

○ Classified pathway(s).
↵a Actual major clearance pathways.
↵b Minor clearance pathways that have been published in the literature or documented in drug review reports.
↵c Pathways that have been experimentally confirmed by our group but not yet published.