TABLE 7

The classified and actual major pathway for all drugs investigated

ChargeDrug NameClassified Pathway
CYP3A4CYP2C9CYP2D6RenalOATP
Cation/neutralAcyclovir○a
Cation/neutralAlprazolam○a
Cation/neutralAmicacin○a
Cation/neutralAmiodarone○a
Cation/neutralAmlodipine○a
AnionAmoxicillin○a
Cation/neutralAprepitant○a
Cation/neutralAtazanavir○a
Cation/neutralAtenolol○a
Cation/neutralAtomoxetine○a
AnionAtorvastatin○a
AnionBosentan○a
Cation/neutralBuprenorphine○a
Cation/neutralBuspirone○a
AnionCandesartan○a
Cation/neutralCarbamazepine○a
AnionCefazolin○a
AnionCefdinir○a
AnionCefixime○a
AnionCefotetan○a
AnionCefuroxime○a
Cation/neutralCelecoxib○—a
AnionCephalexin○a
AnionCerivastatin○a
Cation/neutralChloroquine○—a
Cation/neutralChlorpheniramine—a
Cation/neutralChlorpromazine○○a
Cation/neutralChlorthalidone○a
AnionCidofovir○a
Cation/neutralCimetidine○a
Cation/neutralClonazepam○○a
Cation/neutralClonidine○a
AnionDaptomycin○a
Cation/neutralDiazepam○a
AnionDicloxacillin○a○
Cation/neutralDidanosine○a
Cation/neutralDigoxin—a
Cation/neutralDiltiazem○a
Cation/neutralDiphenhydramine○○a
Cation/neutralDofetilide○a
Cation/neutralDonepezil○a
Cation/neutralDoxepin○○a
AnionDoxycycline○a
AnionEnalapril○○a
AnionEnalaprilat○—a
Cation/neutralEplerenone—a
Cation/neutralErythromycin○a
Cation/neutralEthambutol○a
Cation/neutralFelodipine○a
Cation/neutralFinasteride○a
Cation/neutralFlecainide—a○
Cation/neutralFluconazole○a
Cation/neutralFluoxetine○○a
Cation/neutralFluphenazine○—a
AnionFluvastatin○a
AnionFoscarnet○a
AnionFurosemide○a
Cation/neutralGalantamine—a
Cation/neutralGanciclovir○a
AnionGlimepiride—a○
AnionGlipizide—a○
AnionGlyburide/glibenclamide—a○
Cation/neutralGranisetron—a○
Cation/neutralHydrochlorothiazide○a
AnionIbuprofen○a
Cation/neutralIfosfamide—a○
Cation/neutralImatinib○a
Cation/neutralImipramine○○a
AnionIndomethacin○a
AnionIrbesartan—a○
Cation/neutralItraconazole○a
Cation/neutralKetoconazole○a
AnionKetorolac○a
Cation/neutralLamivudine○a
Cation/neutralLansoprazole○a
Cation/neutralLeflunomide○a
Cation/neutralLevetiracetam○a
Cation/neutralLopinavir○a
Cation/neutralLovastatin○a
AnionMeloxicam○a
Cation/neutralMetformin○a
Cation/neutralMethadone○a
AnionMethotrexate○a
Cation/neutralMethylprednisolone○a
Cation/neutralMetoprolol—a○
Cation/neutralMidazolam○a
AnionMontelukast—a
Cation/neutralNelfinavir○a
Cation/neutralNevirapine○a
Cation/neutralNifedipine○a
Cation/neutralNortriptyline○○a
AnionOlmesartan○a
Cation/neutralOndansetron○a
Cation/neutralOxybutynin○a
Cation/neutralOxycodone—a
Cation/neutralParoxetine○a
AnionPenicillin G○a
AnionPhenytoin○a
AnionPitavastatin○a
Cation/neutralPramipexole○a
AnionPravastatin○○a
Cation/neutralPrednisolone○a
Cation/neutralPrednisone○a
Cation/neutralProcainamide○a
Cation/neutralPropranolol—a
Cation/neutralQuetiapine○a
Cation/neutralQuinidine○a
Cation/neutralQuinine○a
Cation/neutralRanitidine○a
AnionRepaglinide○a
AnionRifampin○○a
AnionRisedronate○a
Cation/neutralRisperidone○—a
Cation/neutralRitonavir○a
AnionRosuvastatin○○a
Cation/neutralSildenafil○a
AnionSimvastatin acid○a
Cation/neutralSirolimus○a
Cation/neutralTacrolimus○a
Cation/neutralTadalafil○a
Cation/neutralTamoxifen○a
Cation/neutralTamsulosin—a
AnionTelmisartan○a
AnionTemocapril○a
AnionTemocaprilat○○a
AnionTenofovir○a
Cation/neutralTimolol—a○
AnionTolbutamide○a
Cation/neutralTolterodine○○a
Cation/neutralTopiramate—a
Cation/neutralTopotecan○a
Cation/neutralToremifene○a
Cation/neutralTrazodone○a
Cation/neutralTrimethoprim○a
AnionValsartan○a
Cation/neutralVenlafaxine—a
Cation/neutralVerapamil○a
Cation/neutralVincristine○a
Cation/neutralVinorelbine○a
AnionWarfarin○a
Cation/neutralZolpidem○a

  • ○ Classified pathway(s).

  • ↵a Actual major clearance.