TABLE 2

Dose-normalized C_max and AUC of tolterodine, 5-HM, and active moiety in each genotype

Data are presented as mean (SD) and [95% CI]. If the number of subjects is less than 2, individual values are shown instead of a descriptive summary.

Genotype	Tolterodine		5-HM		Active Moiety
Genotype	C_max	AUC_0–24	C_max	AUC_0–24	C_max	AUC_0–24
	ng/ml	ng · h/ml	ng/ml	ng · h/ml	nM	nM · h
1/1 (n = 45)	1.65 (2.66)	17.05 (33.66)	2.09 (1.24)	21.39 (10.44)	2.35 (1.01)	24.23 (8.60)
	[0.85–2.45]	[6.93–27.16]	[1.72–2.47]	[18.26–24.53]	[2.04–2.65]	[21.65–26.82]
1/10 (n = 31)	1.64 (0.92)	17.18 (8.80)	2.11 (0.84)	24.18 (7.79)	2.74 (1.10)	31.39 (10.73)^*
	[1.30–1.98]	[13.95–20.40]	[1.80–2.41]	[21.32–27.04]	[2.33–3.14]	[27.45–35.33]
1/4 or 1/5 (n = 15)	3.18 (2.08)	33.63 (29.04)	2.28 (1.05)	26.70 (7.50)	3.02 (1.24)	35.40 (9.55)^*]
	[2.03–4.33]	[17.54–49.71]	[1.70–2.85]	[22.54–30.85]	[2.33–3.71]	[30.11–40.70]
10/10 (n = 13)	4.31 (2.87)^*^†	51.83 (36.26)^*^†	2.33 (0.87)	31.36 (10.57)^*	3.35 (1.51)^*	44.23 (18.36)^*^†
	[2.58–6.04]	[29.92–73.74]	[1.80–2.85]	[24.97–37.75]	[2.44–4.26]	[33.14–55.33]
5/10 (n = 2)	6.06, 6.34	79.04, 87.09	1.89, 2.25	26.84, 32.24	2.89, 3.84	40.19, 54.92
4/4 (n = 2)	17.82, 18.84	346.10, 358.94	N.A.	N.A.	1.52, 1.60	29.54, 30.64

N.A., not applicable.
↵* Significantly higher than CYP2D6*1/*1 using the Bonferroni post hoc test (P < 0.05).
↵† Significantly higher than CYP2D6*1/*10.