Genotype | Tolterodine | 5-HM | Active Moiety | |||
---|---|---|---|---|---|---|
Cmax | AUC0–24 | Cmax | AUC0–24 | Cmax | AUC0–24 | |
ng/ml | ng · h/ml | ng/ml | ng · h/ml | nM | nM · h | |
*1/*1 (n = 45) | 1.65 (2.66) | 17.05 (33.66) | 2.09 (1.24) | 21.39 (10.44) | 2.35 (1.01) | 24.23 (8.60) |
[0.85–2.45] | [6.93–27.16] | [1.72–2.47] | [18.26–24.53] | [2.04–2.65] | [21.65–26.82] | |
*1/*10 (n = 31) | 1.64 (0.92) | 17.18 (8.80) | 2.11 (0.84) | 24.18 (7.79) | 2.74 (1.10) | 31.39 (10.73)* |
[1.30–1.98] | [13.95–20.40] | [1.80–2.41] | [21.32–27.04] | [2.33–3.14] | [27.45–35.33] | |
*1/*4 or *1/*5 (n = 15) | 3.18 (2.08) | 33.63 (29.04) | 2.28 (1.05) | 26.70 (7.50) | 3.02 (1.24) | 35.40 (9.55)*] |
[2.03–4.33] | [17.54–49.71] | [1.70–2.85] | [22.54–30.85] | [2.33–3.71] | [30.11–40.70] | |
*10/*10 (n = 13) | 4.31 (2.87)*† | 51.83 (36.26)*† | 2.33 (0.87) | 31.36 (10.57)* | 3.35 (1.51)* | 44.23 (18.36)*† |
[2.58–6.04] | [29.92–73.74] | [1.80–2.85] | [24.97–37.75] | [2.44–4.26] | [33.14–55.33] | |
*5/*10 (n = 2) | 6.06, 6.34 | 79.04, 87.09 | 1.89, 2.25 | 26.84, 32.24 | 2.89, 3.84 | 40.19, 54.92 |
*4/*4 (n = 2) | 17.82, 18.84 | 346.10, 358.94 | N.A. | N.A. | 1.52, 1.60 | 29.54, 30.64 |