Estimated intrinsic clearances of CYP2D6 for tolterodine and for 5-HM and the relative enzyme activity to CYP2D6*1/*1 in each genotype
Data are presented as mean (SD). If the number of subject is less than 2, individual values are shown instead of a descriptive summary.
| Genotype | Tolterodine | 5-HM | ||
|---|---|---|---|---|
| CLintCYP2D6, tolterodine | Relative Enzyme Activity | CLintCYP2D6, 5-HM | Relative Enzyme Activity | |
| l/h | % | l/h | % | |
| *1/*1 (n = 45) | 4441 (1479) | 100 | 131 (55) | 100 |
| *1/*10 (n = 31) | 2898 (1136) | 65 | 89 (59) | 68 |
| *1/*4 or *1/*5 (n = 15) | 2121 (984) | 48 | 68 (43) | 52 |
| *10/*10 (n = 13) | 1594 (1287) | 36 | 48 (51) | 37 |
| *5/*10 (n = 2) | 435, 729 | 10, 16 | 0, 33 | 0, 25 |