TABLE 1

Pharmacokinetic and biliary excretion parameters of TA-0201CA in SDR and EHBR

TA-0201CA was intravenously administered to bile duct-cannulated SDR at a dose of 1 mg/kg. Data are shown as the mean ± S.E.M. (n = 3 animals).

SDREHBR
Pharmacokinetic parameters
    t1/2 (min)34.4 ± 1.193.3 ± 3.8*
    AUC (μg/ml · min)76.2 ± 12.1681.1 ± 56.8*
    CLtot (ml/min/kg)14.0 ± 2.71.5 ± 0.2*
    MRT (min)9.7 ± 0.7119.5 ± 6.8*
    Vdss (ml/kg)134.2 ± 23.2181.5 ± 18.0
    fp0.0040.004
Biliary excretion parameters
    Excretion ratio0–180 min (% of dose)97.5 ± 1.846.8 ± 8.9*
    CLbile (ml/min/kg)13.6 ± 2.30.9 ± 0.1*
    CLbile, int (l/min/kg)4347.7 ± 946.2227.7 ± 27.3*

  • ↵* p < 0.05 versus SDR.