Liver/plasma concentration ratio of TA-0201CA after intravenous administration of TA-0201CA to SDR at the dose of 1 mg/kg
The concentrations of TA-0201CA in plasma and liver were determined 3 h after administration, and liver/plasma concentration ratio (Kp) values were calculated. Data are shown as the mean ± S.E.M. (n = 3 animals).
| Concentration | Unbound Fraction | ||
|---|---|---|---|
| Total | Unbound | ||
| ng/ml | |||
| Plasma | 254.1 ± 94.4 | 1.0 ± 0.4 | 0.004 |
| Liver | 2996.2 ± 700.2 | 41.9 ± 9.8 | 0.014 |
| Kp (liver/plasma) | 13.1 ± 1.9 | 46.0 ± 6.8 | |