TABLE 3
Metabolism and metabolic activation of 2-aminothiophene derivatives in rat liver microsomes in the presence of GSH or NAC
| Compound | Structure | %GSH Adduct | %NAC Adduct | Major Metabolism |
|---|---|---|---|---|
| 7 |  | No | No | |
| 8 |  | No | No | Ester hydrolysis |
| 9 |  | No | No | N-Demethylation |
| 10 |  | No | No |