TABLE 4
Metabolism and metabolic activation of 2,4-diaminothiophene derivatives in rat liver microsomes in the presence of GSH
| Compound | Structure | %GSH Adduct | Major Metabolism |
|---|---|---|---|
| 11 |  | No | Oxidation |
| 12 |  | No | |
| 13 |  | No | |
| 14 |  | No |
Metabolism and metabolic activation of 2,4-diaminothiophene derivatives in rat liver microsomes in the presence of GSH
| Compound | Structure | %GSH Adduct | Major Metabolism |
|---|---|---|---|
| 11 | | No | Oxidation |
| 12 | | No | |
| 13 | | No | |
| 14 | | No |