Differential toxicity of CAR-null mice compared with wild-type mice treated with 5 mg/kg/day parathion for 2 consecutive days
Data are shown as number of mice showing toxicity/number of mice treated.
| Treatment | WT (M) | CAR-Null (M) | WT (F) | CAR-Null (F) |
|---|---|---|---|---|
| 0 mg/kg/day | 0/5 | 0/5 | 0/5 | 0/5 |
| 3 mg/kg TCPOBOP | 0/4 | 0/5 | 0/4 | 0/5 |
| 5 mg/kg/day parathion | 0/5* | 4/4* | 2/5* | 5/5* |
| 20 mg/kg/day parathion | 4/4 | 4/4 |
M, male; F, female.
↵* Statistical significance was assessed by Mann-Whitney rank-sum tests using toxicity rankings depending on the severity: 1 = not toxic; 2 = eye leakage; 3 = lethargy; slow movements or tremors; and 4 = death. Male and female data, p = 0.0079.