TABLE 1

MRM transitions and mass spectrometry parameters for the metabolites and their internal standards in the LC-MS/MS method

Analyte	Internal Standard	MRM Transition		Dwell Time	Fragmentor	Collision Energy
Analyte	Internal Standard	Analyte	Internal Standard	Dwell Time	Fragmentor	Collision Energy
		m/z	m/z	ms	V
N-Desethylamodiaquine	[²H₅]N-Desethylamodiaquine	328 > 283	333 > 283	100	113	14
Acetaminophen	[²H₄]Acetaminophen	152 > 110	156 > 114	100	96	14
Hydroxybupropion	[²H₃]Hydroxybupropion	256 > 238	259 > 241	100	76	10
4-Hydroxymephenytoin	[²H₃]4-Hydroxymephenytoin	235 > 150	238 > 150	100	102	14
5-Hydroxypropafenone	[²H₇]5-Hydroxypropafenone	358 > 116	365 > 123	50	141	18
Hydroxytolbutamide	[²H₉]Hydroxytolbutamide	287 > 89	296 > 89	100	96	42
o-Hydroxyatorvastatin	[²H₅]o-Hydroxyatorvastatin	575 > 440	580 > 445	200	156	18