Pathological grade of increased extramedullary hematopoiesis in the spleen after DCNB treatment for 14 days
Grade 0, no change compared with the control (0 mg/kg); grade 1, slight change; grade 2, moderate change; grade 3, marked change.
| Dose Levels of DCNB | 150 mg/kg | 300 mg/kg | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Grade | 0 | 1 | 2 | 3 | No. Examined | 0 | 1 | 2 | 3 | No. Examined |
| Male | ||||||||||
| Wild-type | 5 | 1 | 6 | |||||||
| Gstm1-null | 5 | 5 | ||||||||
| Female | ||||||||||
| Wild-type | 2 | 4 | 6 | 3 | 3 | 6 | ||||
| Gstm1-null | 2 | 4 | 6 | 3 | 3 | 6 | ||||