TABLE 1

Experimental groups for evaluating talinolol pharmacokinetics in rats

No. Animals	Talinolol			P-Glycoprotein Inhibitor
No. Animals	Dose	Administration Mode	Formulation^{^a}	Compound	Dose	Administration Mode
	mg/kg				mg/kg
6	4	i.v.	A
6	2	i.v.	A	Verapamil	5	p.o.
4	2	i.v.	A	Cyclosporine	100	p.o.
6	40	p.o.	B
5	40	p.o.	B	Verapamil	5	p.o.
6	40	p.o.	B	Cyclosporine	100	p.o.
5	40	Cecum infusion over 4 h	B
5	40	Cecum infusion over 4 h	B	Cyclosporine	100	Cecum bolus
6	4	p.o.	C
5	4	p.o.	C	Verapamil	5	p.o.
9	4	p.o.	C	Cyclosporine	100	p.o.

↵a Formulations of talinolol: A, 2 mg/ml solution in 40% sodium phosphate buffer 0.2 M, pH 7, 40% propylene glycol and 20% ethanol; B, 8 mg/ml solution in 25% polyethylene glycol 400, 15% ethanol, and 60% water; and C, 1 mg/ml solution in 25% polyethylene glycol 400, 15% ethanol, and 60% water.