Pharmacokinetic parameters of compound 1, M1a-1, and M1a-2 in Sprague-Dawley rats after a single 2 mg/kg intravenous dose
| Parameters | Compound 1 | M1a-1 | M1a-2 |
|---|---|---|---|
| CLs (l/h/kg) | 2.3 ± 0.2 | 6.4 ± 0.8 | 7.4 ± 1.9 |
| Vdss (l/kg) | 2.4 ± 0.3 | 1.5 ± 0.4 | 0.9 ± 0.3 |
| AUC0–∞ (ng · h/ml) | 867 ± 73 | 315 ± 36 | 283 ± 64 |
| Half-life (h) | 0.9 ± 0.1 | 0.7 ± 0.1 | 0.2 ± 0.1 |